abstract：:Applications of laser therapy, including low-level laser therapy (LLLT), phototherapy and photodynamic therapy (PDT), have been proven to be beneficial and relatively less invasive therapeutic modalities for numerous diseases and disease conditions. Using specific types of laser irradiation, specific cellular activiti...

journal_title：International journal of molecular sciences

authors： Kushibiki T,Hirasawa T,Okawa S,Ishihara M

更新日期：2013-06-27 00:00:00

abstract：:Growing evidence shows a close association of transposable elements (TE) with non-coding RNAs (ncRNA), and a significant number of small ncRNAs originate from TEs. Further, ncRNAs linked with TE sequences participate in a wide-range of regulatory functions. Alu elements in particular are critical players in gene regul...

journal_title：International journal of molecular sciences

authors： Hadjiargyrou M,Delihas N

更新日期：2013-06-26 00:00:00

abstract：:Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were ...

journal_title：International journal of molecular sciences

authors： Chen JJ,Ting CW,Wu YC,Hwang TL,Cheng MJ,Sung PJ,Wang TC,Chen JF

更新日期：2013-06-25 00:00:00

abstract：:Plant mitochondrial NAD-malic enzyme (NAD-ME), which is composed of α- and β-subunits in many species, participates in many plant biosynthetic pathways and in plant respiratory metabolism. However, little is known about the properties of woody plant NAD-MEs. In this study, we analyzed four NAD-ME genes (PtNAD-ME1 thro...

journal_title：International journal of molecular sciences

authors： Liu J,Yu Q,Elsheery NI,Cheng Y

更新日期：2013-06-24 00:00:00

abstract：:The development of atherosclerosis is a multi-step process, at least in part controlled by the vascular endothelium function. Observations in humans and experimental models of atherosclerosis have identified monocyte recruitment as an early event in atherogenesis. Chronic inflammation is associated with ageing and its...

journal_title：International journal of molecular sciences

authors： Corbi G,Bianco A,Turchiarelli V,Cellurale M,Fatica F,Daniele A,Mazzarella G,Ferrara N

更新日期：2013-06-17 00:00:00

abstract：:The TiO2-montmorillonite (TiO2-MMT) complex was prepared by blending TiO2 sol and MMT with certain ratio, and its properties as an enzyme immobilization support were investigated. The pristine MMT and TiO2-MMT calcined at 800 °C (TiO2-MMT800) were used for comparison to better understand the immobilization mechanism. ...

journal_title：International journal of molecular sciences

authors： Wang Q,Peng L,Li G,Zhang P,Li D,Huang F,Wei Q

更新日期：2013-06-14 00:00:00

abstract：:Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong to the super family of G-protein-coupled receptors consisting of the typical seven transmembrane domains. MT1 and MT2 receptors are expressed in various tissues of the body either as single ones or together. A growing literature su...

journal_title：International journal of molecular sciences

authors： De Berardis D,Marini S,Fornaro M,Srinivasan V,Iasevoli F,Tomasetti C,Valchera A,Perna G,Quera-Salva MA,Martinotti G,di Giannantonio M

更新日期：2013-06-13 00:00:00

abstract：:In this study, the immuno-modulatory and anticancer activities of marine algae, Spirulina maxima grown in deep-sea water (DSW), were investigated. It was found that the extract of S. maxima, cultured in DSW, effectively suppressed the expression of Bcl2 in A549 cells as well as inhibiting various human cancer cells wi...

journal_title：International journal of molecular sciences

authors： Choi WY,Kang DH,Lee HY

更新日期：2013-06-06 00:00:00

abstract：:(-)-Epigallocatechin gallate (EGCG) and curcumin are two naturally derived agents that have been widely investigated worldwide. They exhibit their anti-tumor effects in many types of cancers. In the current study, the effect of the combination of the two agents on non-small cell lung cancer (NSCLC) cells was investiga...

journal_title：International journal of molecular sciences

authors： Zhou DH,Wang X,Yang M,Shi X,Huang W,Feng Q

更新日期：2013-06-05 00:00:00

abstract：:Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investiga...

journal_title：International journal of molecular sciences

authors： Ibeawuchi C,Schmidt H,Voss R,Titze U,Abbas M,Neumann J,Eltze E,Hoogland AM,Jenster G,Brandt B,Semjonow A

更新日期：2013-06-03 00:00:00

abstract：:Molecular Dynamics is a method of choice for membrane simulations and the rising of coarse-grained forcefields has opened the way to longer simulations with reduced calculations times. Here, we present an elastic network, SAHBNET (Surface Accessibility Hydrogen-Bonds elastic NETwork), that will maintain the structure ...

journal_title：International journal of molecular sciences

authors： Dony N,Crowet JM,Joris B,Brasseur R,Lins L

更新日期：2013-05-30 00:00:00

abstract：:Monoclonal antibody G250 (mAbG250) recognizes a determinant on carbonic anhydrase IX (CAIX). CAIX is expressed by virtually all renal cell carcinomas of the clear cell type (ccRCC), but expression in normal tissues is restricted. The homogeneous CAIX expression in ccRCC and excellent targeting capability of mAbG250 in...

journal_title：International journal of molecular sciences

authors： Oosterwijk-Wakka JC,Boerman OC,Mulders PF,Oosterwijk E

更新日期：2013-05-29 00:00:00

abstract：:Cisplatin is one of the most widely used chemical drugs for anticancer treatment. Recent studies have focused on the ability of cisplatin to retain the high mobility group box 1 (HMGB1) protein in cisplatin-DNA adducts, thereby preventing its release from the nucleus. Because HMGB1 is a powerful inflammatory mediator ...

journal_title：International journal of molecular sciences

authors： Li X,Wang LK,Wang LW,Han XQ,Yang F,Gong ZJ

更新日期：2013-05-27 00:00:00

abstract：:Oxidative damages induced by a redox imbalance cause age-related changes in cells and tissues. Superoxide dismutase (SOD) enzymes play a major role in the antioxidant system and they also catalyze superoxide radicals (O2·-). Since the loss of cytoplasmic SOD (SOD1) resulted in aging-like phenotypes in several types of...

journal_title：International journal of molecular sciences

authors： Watanabe K,Shibuya S,Koyama H,Ozawa Y,Toda T,Yokote K,Shimizu T

更新日期：2013-05-24 00:00:00

abstract：:A flexible methacrylate powder dressing (Altrazeal®) transforms into a wound contour conforming matrix once in contact with wound exudate. We hypothesised that it may also serve as a drug delivery vehicle for antiseptics. The antimicrobial efficacy and influence on bacterial growth kinetics in combination with three a...

journal_title：International journal of molecular sciences

authors： Forstner C,Leitgeb J,Schuster R,Dosch V,Kramer A,Cutting KF,Leaper DJ,Assadian O

更新日期：2013-05-21 00:00:00

abstract：:It has been confirmed that alternatively activated macrophages (M2) participate in tissue remodeling and fibrosis occurrence, but the effect of M2 on peritoneal fibrosis related to peritoneal dialysis (PD) hasn't been elucidated. This study was therefore conducted to assess the association between M2 and peritoneal fi...

journal_title：International journal of molecular sciences

authors： Wang J,Jiang ZP,Su N,Fan JJ,Ruan YP,Peng WX,Li YF,Yu XQ

更新日期：2013-05-17 00:00:00

abstract：:Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar. Insect herbivory induce...

journal_title：International journal of molecular sciences

authors： Fürstenberg-Hägg J,Zagrobelny M,Bak S

更新日期：2013-05-16 00:00:00

abstract：:The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast majority localizing to intracellular organelles. GLUT4 is retained intr...

journal_title：International journal of molecular sciences

authors： Sadler JB,Bryant NJ,Gould GW,Welburn CR

更新日期：2013-05-10 00:00:00

abstract：:Adsorption of precious metals in acidic aqueous solutions using thiourea modified magnetic magnetite nanoparticle (MNP-Tu) was examined. The MNP-Tu was synthesized, characterized and examined as a reusable adsorbent for the recovery of precious metals. The adsorption kinetics were well fitted with pseudo second-order e...

journal_title：International journal of molecular sciences

authors： Lin TL,Lien HL

更新日期：2013-05-08 00:00:00

abstract：:Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement o...

journal_title：International journal of molecular sciences

authors： Kravtsov DV,Ameen NA

更新日期：2013-05-03 00:00:00

abstract：:One of the most common causes of mortality and morbidity in children is perinatal hypoxia-ischemia (HI). In spite of the advances in neonatology, its incidence is not diminishing, generating a pediatric population that will require an extended amount of chronic care throughout their lifetime. For this reason, new and ...

journal_title：International journal of molecular sciences

authors： Alonso-Alconada D,Alvarez A,Arteaga O,Martínez-Ibargüen A,Hilario E

更新日期：2013-04-29 00:00:00

abstract：:The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells was investigated. The enrichment of mast cells with different PUFA including α-linolenic acid (LNA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), linoleic acid (LA) or arachidonic...

journal_title：International journal of molecular sciences

authors： Basiouni S,Fuhrmann H,Schumann J

更新日期：2013-04-25 00:00:00

abstract：:The enolase2 gene is usually expressed in mature neurons and also named neuron specific enolase (NSE). In the present study, we first obtained the NSE gene cDNA sequence by using the RACE method based on the expressed sequence tag (EST) fragment from the cDNA library of Gekko japonicus and identified one transcript of...

journal_title：International journal of molecular sciences

authors： Li J,Wu R,Chen H,Zhou Y,Li Y,Wang Y,Liu Y,Liu M

更新日期：2013-04-24 00:00:00

abstract：:Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery. Incorporation of the unique properties of HNPs into thermally responsive scaffolds holds great potential for future biomedical applications. Here we successfully fabri...

journal_title：International journal of molecular sciences

authors： Roach P,McGarvey DJ,Lees MR,Hoskins C

更新日期：2013-04-19 00:00:00

abstract：:The purpose of this study was to assess the in vitro antimicrobial activity of alkaloid-enriched extracts from Prosopis juliflora (Fabaceae) pods in order to evaluate them as feed additives for ruminants. As only the basic chloroformic extract (BCE), whose main constituents were juliprosopine (juliflorine), prosoflori...

journal_title：International journal of molecular sciences

authors： Dos Santos ET,Pereira ML,da Silva CF,Souza-Neta LC,Geris R,Martins D,Santana AE,Barbosa LC,Silva HG,Freitas GC,Figueiredo MP,de Oliveira FF,Batista R

更新日期：2013-04-17 00:00:00

abstract：:A new approach for encoding DNA sequences as input for DNA sequence analysis is proposed using the error correction coding theory of communication engineering. The encoder was designed as a convolutional code model whose generator matrix is designed based on the degeneracy of codons, with a codon treated in the model ...

journal_title：International journal of molecular sciences

authors： Liu X,Geng X

更新日期：2013-04-16 00:00:00

abstract：:The Asian cycads are mostly allopatric, distributed in small population sizes. Hybridization between allopatric species provides clues in determining the mechanism of species divergence. Horticultural introduction provides the chance of interspecific gene flow between allopatric species. Two allopatrically eastern Asi...

journal_title：International journal of molecular sciences

authors： Chiang YC,Huang BH,Chang CW,Wan YT,Lai SJ,Huang S,Liao PC

更新日期：2013-04-15 00:00:00

abstract：:We have extracted an extensive collection of recurrent structural motifs (RSMs), which consist of sequentially non-contiguous structural motifs (4-6 residues), each of which appears with very similar conformation in three or more mutually unrelated protein structures. We find that the proteins in our set are covered t...

journal_title：International journal of molecular sciences

authors： Johansson MU,Zoete V,Guex N

更新日期：2013-04-10 00:00:00

abstract：:The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic...

journal_title：International journal of molecular sciences

authors： Daiber A,Daub S,Bachschmid M,Schildknecht S,Oelze M,Steven S,Schmidt P,Megner A,Wada M,Tanabe T,Münzel T,Bottari S,Ullrich V

更新日期：2013-04-08 00:00:00

abstract：:In the protozoan ciliate Euplotes, a transduction pathway resulting in a mitogenic cell growth response is activated by autocrine receptor binding of cell type-specific, water-borne signaling protein pheromones. In Euplotes raikovi, a marine species of temperate waters, this transduction pathway was previously shown t...

journal_title：International journal of molecular sciences

authors： Candelori A,Luporini P,Alimenti C,Vallesi A

更新日期：2013-04-03 00:00:00

abstract：:Agricultural production continues to be constrained by a number of biotic and abiotic factors that can reduce crop yield quantity and quality. Potassium (K) is an essential nutrient that affects most of the biochemical and physiological processes that influence plant growth and metabolism. It also contributes to the s...

journal_title：International journal of molecular sciences

authors： Wang M,Zheng Q,Shen Q,Guo S

更新日期：2013-04-02 00:00:00

abstract：:Rho family GTPases belong to the Ras GTPase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. The three best-characterized Rho family members ...

journal_title：International journal of molecular sciences

authors： Chi X,Wang S,Huang Y,Stamnes M,Chen JL

更新日期：2013-03-28 00:00:00

abstract：:Forty mice were randomly divided into four groups on the basis of the diet to be fed as follows: 5% (low) fat diet (T1: LF); 20% (high) fat diet (T2: HF); 20% fat containing 1% conjugated linoleic acid (CLA) (T3: HFC); and 20% fat containing 1% CLA with 0.5% biopolymers (T4: HFCB). The high-fat with CLA diet groups (H...

journal_title：International journal of molecular sciences

authors： Hur SJ,Kim DH,Chun SC,Lee SK

更新日期：2013-03-26 00:00:00

abstract：:Several studies have demonstrated that basic fibroblast growth factor (bFGF) can induce neural differentiation of mesenchymal stem cells. In this study, we investigated the neural differentiation of muscle-derived stem cells (MDSCs) following treatment with bFGF and ethosuximide, a small molecule used as an anticonvul...

journal_title：International journal of molecular sciences

authors： Kang ML,Kwon JS,Kim MS

更新日期：2013-03-25 00:00:00

abstract：:The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-t...

journal_title：International journal of molecular sciences

authors： Carrara M,Prischi F,Ali MM

更新日期：2013-03-21 00:00:00

abstract：:Over the years, anthropogenic factors have led to cadmium (Cd) accumulation in the environment causing various health problems in humans. Although Cd is not a Fenton-like metal, it induces oxidative stress in various animal models via indirect mechanisms. The degree of Cd-induced oxidative stress depends on the dose, ...

journal_title：International journal of molecular sciences

authors： Nair AR,Degheselle O,Smeets K,Van Kerkhove E,Cuypers A

更新日期：2013-03-18 00:00:00

abstract：:Early exercise is an effective strategy for stroke treatment, but the underlying mechanism remains poorly understood. Apoptosis plays a critical role after stroke. However, it is unclear whether early exercise inhibits apoptosis after stroke. The present study investigated the effect of early exercise on apoptosis ind...

journal_title：International journal of molecular sciences

authors： Zhang P,Zhang Y,Zhang J,Wu Y,Jia J,Wu J,Hu Y

更新日期：2013-03-15 00:00:00

abstract：:This study aimed to investigate the effects of cyclopamine, a specific inhibitor of Hedgehog signaling pathways, on the chondrogenic differentiation of mesenchymal stem cells (MSCs). During culture, the experimental groups were treated with cyclopamine and their cell proliferation status was assessed using the MTT tes...

journal_title：International journal of molecular sciences

authors： Wu X,Cai ZD,Lou LM,Chen ZR

更新日期：2013-03-14 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving APP within the Aβ domai...

journal_title：International journal of molecular sciences

authors： Grimm MO,Haupenthal VJ,Rothhaar TL,Zimmer VC,Grösgen S,Hundsdörfer B,Lehmann J,Grimm HS,Hartmann T

更新日期：2013-03-13 00:00:00

abstract：:The mechanism of the chemical reaction of H2O with three stabilized Criegee intermediates (stabCI-OO, stabCI-CH3-OO and stabCIx-OO) produced via the limonene ozonolysis reaction has been investigated using ab initio and DFT (Density Functional Theory) methods. It has been shown that the formation of the hydrogen-bonde...

journal_title：International journal of molecular sciences

authors： Jiang L,Lan R,Xu YS,Zhang WJ,Yang W

更新日期：2013-03-12 00:00:00